Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.
Identifieur interne : 001292 ( Main/Exploration ); précédent : 001291; suivant : 001293Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.
Auteurs : Xing-Lou Yang [République populaire de Chine] ; Ben Hu [République populaire de Chine] ; Bo Wang [République populaire de Chine] ; Mei-Niang Wang [République populaire de Chine] ; Qian Zhang [République populaire de Chine] ; Wei Zhang [République populaire de Chine] ; Li-Jun Wu [République populaire de Chine] ; Xing-Yi Ge [République populaire de Chine] ; Yun-Zhi Zhang [République populaire de Chine] ; Peter Daszak [États-Unis] ; Lin-Fa Wang [Singapour] ; Zheng-Li Shi [République populaire de Chine]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Analyse de séquence d'ADN, Animaux, Attachement viral, Chiroptera (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (isolement et purification), Coronavirus (physiologie), Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus (génétique), Humains, Lignée cellulaire, Peptidyl-Dipeptidase A (métabolisme), Phylogénie, Récepteurs viraux (métabolisme), Similitude de séquences, Virus du SRAS (génétique).
- MESH :
- génétique : ARN viral, Coronavirus, Glycoprotéine de spicule des coronavirus, Virus du SRAS.
- isolement et purification : Coronavirus.
- métabolisme : Peptidyl-Dipeptidase A, Récepteurs viraux.
- physiologie : Coronavirus.
- virologie : Chiroptera.
- Analyse de séquence d'ADN, Animaux, Attachement viral, Coronavirus, Données de séquences moléculaires, Humains, Lignée cellulaire, Phylogénie, Similitude de séquences.
English descriptors
- KwdEn :
- Animals, Cell Line, Chiroptera (virology), Coronavirus (classification), Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus (physiology), Humans, Molecular Sequence Data, Peptidyl-Dipeptidase A (metabolism), Phylogeny, RNA, Viral (genetics), Receptors, Virus (metabolism), SARS Virus (genetics), Sequence Analysis, DNA, Sequence Homology, Spike Glycoprotein, Coronavirus (genetics), Virus Attachment.
- MESH :
- chemical , genetics : RNA, Viral, Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- classification : Coronavirus.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : Coronavirus.
- physiology : Coronavirus.
- virology : Chiroptera.
- Animals, Cell Line, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Virus Attachment.
Abstract
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
DOI: 10.1128/JVI.02582-15
PubMed: 26719272
Affiliations:
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sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Bo" sort="Wang, Bo" uniqKey="Wang B" first="Bo" last="Wang">Bo Wang</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Mei Niang" sort="Wang, Mei Niang" uniqKey="Wang M" first="Mei-Niang" last="Wang">Mei-Niang Wang</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and 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of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Ge, Xing Yi" sort="Ge, Xing Yi" uniqKey="Ge X" first="Xing-Yi" last="Ge">Xing-Yi Ge</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Yun Zhi" sort="Zhang, Yun Zhi" uniqKey="Zhang Y" first="Yun-Zhi" last="Zhang">Yun-Zhi Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yunnan Institute of Endemic Diseases Control and Prevention, Dali</wicri:regionArea><wicri:noRegion>Dali</wicri:noRegion></affiliation></author><author><name sortKey="Daszak, Peter" sort="Daszak, Peter" uniqKey="Daszak P" first="Peter" last="Daszak">Peter Daszak</name><affiliation wicri:level="2"><nlm:affiliation>EcoHealth Alliance, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>EcoHealth Alliance, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name><affiliation wicri:level="1"><nlm:affiliation>Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China zlshi@wh.iov.cn.</nlm:affiliation><country wicri:rule="url">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chiroptera (virology)</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus (physiology)</term><term>Humans</term><term>Molecular Sequence Data</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Phylogeny</term><term>RNA, Viral (genetics)</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (genetics)</term><term>Sequence Analysis, DNA</term><term>Sequence Homology</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Virus Attachment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Attachement viral</term><term>Chiroptera (virologie)</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (isolement et purification)</term><term>Coronavirus (physiologie)</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Humains</term><term>Lignée cellulaire</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Phylogénie</term><term>Récepteurs viraux (métabolisme)</term><term>Similitude de séquences</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Coronavirus</term><term>Glycoprotéine de spicule des coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Analysis, DNA</term><term>Sequence Homology</term><term>Virus Attachment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Attachement viral</term><term>Coronavirus</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Similitude de séquences</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Singapour</li><li>États-Unis</li></country><region><li>Hubei</li><li>État de New York</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name></region><name sortKey="Ge, Xing Yi" sort="Ge, Xing Yi" uniqKey="Ge X" first="Xing-Yi" last="Ge">Xing-Yi Ge</name><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><name sortKey="Wang, Bo" sort="Wang, Bo" uniqKey="Wang B" first="Bo" last="Wang">Bo Wang</name><name sortKey="Wang, Mei Niang" sort="Wang, Mei Niang" uniqKey="Wang M" first="Mei-Niang" last="Wang">Mei-Niang Wang</name><name sortKey="Wu, Li Jun" sort="Wu, Li Jun" uniqKey="Wu L" first="Li-Jun" last="Wu">Li-Jun Wu</name><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><name sortKey="Zhang, Yun Zhi" sort="Zhang, Yun Zhi" uniqKey="Zhang Y" first="Yun-Zhi" last="Zhang">Yun-Zhi Zhang</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Daszak, Peter" sort="Daszak, Peter" uniqKey="Daszak P" first="Peter" last="Daszak">Peter Daszak</name></region></country><country name="Singapour"><noRegion><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26719272
|texte= Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26719272" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |